What is iTHRIV?
The integrated Translational Health Research Institute of Virginia, or iTHRIV, is a National Institutes of Health (NIH)-funded Clinical and Translational Science Award (CTSA) Program Hub. In practice, iTHRIV is a cross-Commonwealth collaboration between University of Virginia , Virginia Tech, Carilion Clinic, and the Inova Health System. iTHRIV unites the research infrastructure of these flagship institutions with the latest advances in data science to accelerate innovation in health-related research and foster the next generation of collaborative health research professionals.
The mission of iTHRIV is to catalyze and sustain inclusive clinical and translational research through diverse, collaborative team science, innovative data science, and broad workforce development in order to improve human health and promote health equity.
Recognizing the need for a creative and broadly integrated approach to solve large and complex problems, the NIH created the CTSA Program to support research teams tackling system-wide scientific and operational problems in clinical and translational research.
According to the NIH, the CTSA Program aims to:
- Train and cultivate the translational science workforce;
- Engage patients and communities in every phase of the translational process;
- Promote the integration of special and underserved populations in translational research across the human lifespan;
- Innovate processes to increase the quality and efficiency of translational research, particularly of multisite trials; and
- Advance the use of cutting-edge informatics.
The mission of the Research Methods component is to develop and implement high quality research tools and methods. iTHRIV facilitates investigator access to these integrated BERD and RKS resources. The mission of the Research Methods component is to develop and implement high quality research tools and methods. iTHRIV facilitates investigator access to these integrated BERD and RKS resources. With iTHRIV’s commitment to collaboration and education/training, the BERD and RKS will also ensure that research design and analysis are rigorous and that all projects remain inside of regulatory boundaries, without hindering progress. This mission will help the iTHRIV Hub achieve its goal of enabling valid, reliable, and reproducible clinical and translational research which is critical to the success of iTHRIV. The expertise of the named leaders for Research Methods, BERD, and RKS covers a full spectrum of biostatistical concepts, approaches and applications, as well as regulatory knowledge. University of Virginia (UVA) and Virginia Tech Carilion (VTC) have existing track records of providing statistical and regulatory support to investigators. The success of UVA and VTC in providing programs to support researchers will be broadened and synergized within iTHRIV. Further, the integrated expertise in BERD and RKS across iTHRIV institutions allows investigators to be exposed to and supported by an environment providing fundamental research methods as well as cutting edge developments and innovations.
Implementation of high-quality research methods and regulatory excellence is essential to the mission of iTHRIV. Our Research Methods team provides expertise in Biostatistics, Epidemiology, and Research Design (BERD) and Regulatory Knowledge and Support (RKS). iTHRIV will expand the reach of the Research Methods component and strengthen its impact to serve the both populations in rural Appalachian communities and the diverse global populations near the nation’s capital. The Research Methods team will use its expertise in BERD and RKS to facilitate clinical translational research with integration of data science and high-quality methods to improve efficiency, quality, and impact of the research process and ultimately improve human health. BERD and RKS will collaborate with other iTHRIV components through the Research Concierge Services. Our integrated expertise will allow us to develop new processes and tools to share within iTHRIV and across the CTSA network.
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